Rune iconR
Rune

Rune of Venom

Tier 2Difficulty Rating 4/5 · Hard1 SlotOpen combinations tool →
chaos / dotchaosdotchallenge

Monster Modifier & Reward

Monster Modifier
Monsters deal 22% increased Chaos Damage and apply stronger damage over time
Reward
Slightly increased chance for Chaos-themed drops
Type: item

Difficulty impact

High-risk profile. Avoid stacking with other hard runes unless you’re intentionally pushing challenge.
Tip
If runs feel spiky, remove the highest-difficulty rune first, then re-add reward-focused runes one at a time.

Synergies & Conflicts

Synergizes with

aldur toxic 01

Recommended pairings

These are suggested based on shared tags, synergies, and compatible difficulty.

Acquisition & Specs

Source
map drop
Min Area Level
68
Usage Tips

• Costs 1 slot on Remnants.

Related runes